Lose Weight, Kill Yourself, Leave Maybe a 5% Lighter Corpse

(Emphasis mine all over the place below.)

From The Wall Street Journal:

The Food and Drug Administration Monday said Acomplia, a proposed weight-loss drug by Sanofi-Aventis SA, was effective at promoting weight loss but appeared to double the rate of suicidal thoughts and behavior.

And that’s not all!

Rimonabant [the generic name] is designed to help block a chemical in the endocannabinoid system, a physiological system in the body that is believed to play a role in how the body regulates food intake. The FDA is concerned, however, that blocking the same chemical could increase the risk for other problems including mood disorders and neurodegenerative disorders like multiple sclerosis.

And oh, I’m not done yet!

The FDA also said there was a higher rate of other psychiatric side effects among rimonabant users and the drug increased the risk of seizures. The agency said one set of studies showed 26% of patients on the 20-milligram dose of rimonabant reported a psychiatric side effect — ranging from depression to insomnia — compared to 14% of patients in the placebo group.

What’s the upside? A 15-pound weight loss over the course of a year. (People on the placebos lost an average of 3 pounds.) That’s not even 10% of an “obese” person’s body weight, unless said obese person is under 5 feet tall. But they also had “gains” in good cholesterol and lowered triglycerides. No numbers on those, but I’d lay dollars to donuts (mmm, donuts) the patients in the study didn’t make any gains they couldn’t have achieved with moderate exercise. Which, you know, alleviates depression. And is free.

In its briefing document, Sanofi said that the “overall benefits in body weight, waist circumference and metabolic parameters…outweigh the risks that are manageable in clinical practice.”

Wait, I’m confused. Let’s go over this one more time.

Benefits: 15-pound weight loss, slightly improved cholesterol and triglycerides.

Risks: Insomnia, depression, seizures, unspecified mood disorders, neurodegenerative disorders, and fucking suicide.

What outweighs what again?

Acomplia is sold in several European countries and the Paris company is seeking approval to sell the drug in the U.S., a key market that would likely propel it to blockbuster status of $1 billion or more in annual sales.

Oh. Right.

(Thanks to Laurie for the tip.)

Posted in Fat

13 thoughts on “Lose Weight, Kill Yourself, Leave Maybe a 5% Lighter Corpse

  1. Of course the negligable benefits outweigh the definate negatives. We’re supposed to shut up, get skinny at all costs so we can look so good in a casket.

  2. Well, sure moderate exercise would improve health, but it won’t significantly impact weight. And if it doesn’t lower weight, it doesn’t really matter.

    Besides, fat people get depressed anyway. Probably because they live in a society don’t care if fat people kill themselves as long as they buying medication when they do so. All the more reason to approve this drug!

  3. Risks: Insomnia, depression, seizures, unspecified mood disorders, neurodegenerative disorders, and fucking suicide.

    Well, gee, sign me up today! I’m sure the moderate gain in social acceptance I would see from losing 15 pounds would be more than enough to outweigh (har har) my newfound suicidal wishes!

  4. You know what is going to be WORSE!? When they take a poll about the medicine and the majority of women would rather risk suicide and take the stupid stuff than learn body acceptance. This sucks!

  5. Yep. I heard about something quite similar quite a few years back. Some journalist was up in arms about the fact that skinny people who only think they’re fat might take it. No one (apart from me) seemed to be particularly up in arms about fat people taking it.

  6. Maybe this could be prescribed in combination with Alli, and people could knock off a whole 18 pounds while having seizures and soiling themselves.

    Suicide, though. Man. I guess fat is so shameful, the goal is thinning the herd, one way or the other?

  7. Suicide, though. Man. I guess fat is so shameful, the goal is thinning the herd, one way or the other?

    My bf’s immediate (and heavily sarcastic) response was, “Well, if fat people kill themselves, doesn’t that mean everybody wins??”

  8. If I want to have suicidal thoughts, depression, mood disorders and insomnia, I can get all of those without spending an extra cent – I just have to stop taking the anti-depressant I’m on at the moment. Of course, I’ll start eating more to compensate (oddly enough, I don’t tend to enjoy being depressed) so any weight loss benefits their wonder drug will provide are going to be buried under the effects of self-medication through carbohydrate.

  9. Agree with Meg…no Prozac, and I might as well dive headfirst into a vat of Ben & Jerry’s, surfacing only to slap some Brie on crackers and wash it down with a big-ass, non-skim latte.

  10. “You know what is going to be WORSE!? When they take a poll about the medicine and the majority of women would rather risk suicide and take the stupid stuff than learn body acceptance. This sucks!”

    They already took that poll. Remember the teenagers who would “rather be dead than fat”?

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